crazy scalpel

Chapter 113 Local Tyrant

Professor Xu silently took out another bottle of medicine from the drawer and put it on the table.

Xie Ke and Li Shiguang leaned over together to see that it was an oral drug that mimics cholinergic.

The two said in unison: "ad?!"

AD is Alzheimer's disease, which is the abbreviation of Alzheimer's disease. People over the age of 70 belong to the high-onset group, and the onset before the age of 65 belongs to the early onset group.Professor Xu is only in his 50s this year, and he has this disease in his [-]s. No wonder Xie Ke and Li Shiguang were surprised.

The pathogenesis of this disease is still unclear, but studies have shown that psychotropic drugs and nootropic drugs have an effect on delaying the progress of the disease.The drug that Professor Xu is taking is to improve the ability of learning and memory by strengthening the activity of central cholinergic neurons.

It stands to reason that if you have this disease, there will be no immediate danger, but it will gradually erode the memory and cognitive functions of the human brain.There are actually many people suffering from this disease, and not every patient will take medicine for this, because it is said that taking medicine can delay the onset, but in fact it does not have much effect.The general practice is that if there is an AD patient in the family, other members will find ways to give him or her more care until the patient is completely incapacitated and passes away.

Xie Ke could understand Professor Xu's not wanting to have surgery.Although the transnasal-sphenoidal approach does not pose a great threat to death, with Xie Ke or Cai Tianqiao's ability, it has even been 100% successful so far.But no one knows if there will be any surprises if Alzheimer's patients undergo surgery.

Maybe a lack of blood supply or even the slightest infection would make him worse.

Professor Xu has been reluctant to operate for a long time, or he wants to wait for his research to reach the experimental stage, at least to see some light before he is willing to rest assured to do the operation.In this way, even if he becomes stupid and idiotic after waking up, he will not regret it.

Both Xie Ke and Li Shiguang could understand his thinking.But as his students, they obviously couldn't agree.

Li Shiguang: "Teacher, I absolutely disagree with you doing this. You should undergo surgery immediately. This small operation can be completed in just over an hour. If Xie Ke is allowed to do it, I think the problem can be solved in half an hour. Since you can Shortening the operation time can greatly reduce the risk of accelerating the progress of the disease. If you undergo surgery now, at least the hazard of pituitary tumor can be removed immediately, and your vision can be restored, which is also good for your usual work. If you keep procrastinating, say Your life may have been threatened before AD's illness broke out, isn't it worth the loss?"

Professor Xu smiled wryly: "I know what you said, but I just can't make up my mind... I'm afraid too."

Xie Ke puffed up his cheeks, and persuaded: "Brother is right, and Cai Tianqiao is very good at this operation, so you can find him."

Professor Xu knew what he was thinking at a glance, and shook his head: "If I really want to have an operation, why would I look far away? Of course it's you."

Li Shiguang didn't see him either. Anyway, Professor Xu already knew about their relationship, so he put his arm around Xie Ke's waist from behind, and scratched his nose with his hand: "Little vinegar jar."

Shek stared back at him.

Professor Xu gave a fake cough: "Enough is enough for you, you are still stuck together when you are old. Let this matter go, and I will wait and see. If it really doesn't work, choose surgery."

"no!"

Li Shiguang retracted his arms, hugged Xie Ke tightly and shook and said, "Teacher, you really can't delay any longer. This film was shot a month ago. This tumor has grown very badly, and now you always have black shadows in front of your eyes." Dangling around is not suitable for continuing to work!"

Xie Ke then threw out a bombshell: "Yes, teacher, you trust me. Let's have an operation! Actually, I have some good news. I wanted to tell you when I got a little more clues, but now I just tell you about it. Reassurance. My in vitro model experiment of the blood-brain barrier has achieved results! The report and paper have not been written yet. I plan to write the paper while continuing to conduct animal experiments. It happened that I chose Alzheimer’s when I planned the content of the next stage of the experiment. Silent disease animal model..."

Professor Xu jumped up and looked at him in shock: "What did you say?!"

Xie Ke was taken aback, and while leaning into Li Shiguang's arms, he replied: "I said that there is progress in breaking through the blood-brain barrier..."

Professor Xu pointed at him with his finger: "You...you little bastard! Why are you talking about such an important matter now? If you didn't know that I was sick, you still kept it under wraps, didn't you? How did I raise you? A worthless apprentice..."

Seeing that Xie Ke didn't know why, Professor Xu picked up a little puppet of a beautiful sheep on the table and threw it over, but Li Shiguang caught it, "You idiot! Do you know what a big deal this is! What's the use of your small broken laboratory in a hospital in the city! Have you declared to the Chinese Academy of Sciences! How much did you spend on the in vitro model of the blood-brain barrier! You wouldn't use your own money, would you?!"

Xie Ke whispered cowardly: "Anyway, I have a lot of money, and it's useless..."

Professor Xu rolled his eyes—in fact, Li Shiguang did the same thing where Xie Ke couldn't see, but it was too indecent and he wouldn't do it in front of Xie Ke.

Xie Ke thought about it, and in order to save his EQ: "Actually, it's not much use, but the next stage will use a lot of imported experimental animals, so it must be declared to the state and contacted for sponsorship. Especially some Sophisticated instruments cannot be produced domestically, so they must be procured from abroad. It is said that some shrewd foreigners will not sell them if they do not throw some bait to them. This time, international cooperation is probably required. By the way, I think M Group is very good and suitable.”

Xie Ke’s method of establishing an in vitro model of the blood-brain barrier is to add 100 million human brain microvascular endothelial cells to a 2-well culture plate with a pore size of only 12 microns, and then change the culture medium regularly. After 72 hours of culture, these cells will Fusion forms a cell layer, which is similar to a monolayer of endothelial cells in brain microvascular cells.

This model is not very complicated to make, and the laboratory of the No. [-] City Hospital can fully meet the requirements. As for the cost of purchasing cells, culture medium and culture plates, it probably cost several million. He asked Professor Tonut to order it.

In fact, if he really wanted to do this experiment, based on his genius level and the miracles he had created in the past, Dean Liu might not support him.But the time for all kinds of evaluations and collections was too long, and Xie Ke's heart was too itchy, and he wanted to start doing it right away, so he started to do it himself first.

Anyway, as long as there is even a little bit of results, it will definitely cause those institutions and organizations to join in frantically.After entering the second stage, he doesn't have to worry about financial problems at all.And Xie Ke has a lot of savings now, thanks to bone cement and scalp wallets, his account has been receiving money continuously, and now he has transformed into a tall, rich and handsome.Height, 1.7 meters six, is also considered qualified.

Besides, as long as he secretly buys the stock of that company before choosing a pharmaceutical group to cooperate with, and then signs the contract, then he only needs to wait for the stock to rise and rise, and then they will all come back, just a few million, really not counted What!

Although Professor Xu hated Xie Ke's calmness, he was more concerned about the content of the experiment: "Did you really open the blood-brain barrier?"

Xie Ke came back to his senses from the head full of soft sister coins, and replied shyly: "It's not a complete success, it's only a 60.00% success rate. Hehe."

Professor Xu grabbed another lazy puppet and threw it at him again, but was caught by Li Shiguang again. He glared at Li Shiguang and continued to spray Xie Ke: "Hehe, you are big! Do you know, do you know! If this is true, it is, it is... the rhythm of the Nobel Prize!"

Xie Ke licked his face and complimented: "I don't care about the Nobel Prize, it would be nice to have the Professor Xu Award."

Professor Xu laughed angrily at him, and didn't bother with him, "How did you do it? Is it similar to the bubble experiment that Canada is doing recently?"

"No." Xie Ke said: "They use ultrasonic waves to penetrate into the brain and gather them, causing the microbubbles in the blood inside the human body to vibrate at high speed, so as to achieve the purpose of expansion. But the endothelial cells that constitute the blood-brain barrier are forcibly shaken away by external force After that, it takes several hours to return to normal. This period of time is extremely dangerous for the human brain. That is to say, when the blood-brain barrier is opened to allow drugs to enter, some human toxins and harmful substances that were previously isolated are also released. There is also a chance to enter. And my method..."

Professor Xu glared at him.

"Speaking of which, it's all thanks to senior brother." Xie Ke turned to look at Li Shiguang, Li Shiguang stuffed the beautiful sheep and lazy sheep into his arms and said, "This is for you, Li Shiguang Award."

The two of them laughed together. Xie Ke saw that Professor Xu was going to get angry, so he hurriedly continued: "It's the neuroplasticity experiment that brother is doing. Didn't the nerve electricity be used? I was inspired by this, and I wanted to use the nerve electricity in this experiment." Above, after not too many attempts, I was very lucky to find the switch of the blood-brain barrier. Opening the blood-brain barrier by vibration is an external damage, so it takes time to recover, and using bioelectricity to stimulate certain nerves If the yuan makes it open, it belongs to the opening of receiving instructions, as long as the electrical stimulation is withdrawn, it will be closed immediately."

Professor Xu took a deep breath and said in disbelief: "Stimulate neurons with bioelectricity?!"

Xie Ke: "And I also found that when some specific neurons are stimulated with bioelectricity, the degree of opening of the blood-brain barrier is different. When I used different macromolecular proteins for experiments, I found a Coincidentally, if the same molecule is allowed to enter when neurons are continuously stimulated to open the blood-brain barrier in a certain stage, the barrier to it by the blood-brain barrier will become smaller. That is to say, if you want to make a drug Once it enters the brain, it will become easier to stimulate the switch of the blood-brain barrier. This also greatly facilitates the treatment and reduces the chance of harmful substances entering."

"..." Professor Xu: "Little monster! There is no need to say anything! I absolutely support you! If you can make the drug for treating AD break through the blood-brain barrier, I am even willing to be your first experimental subject!"

Shayk grinned: "But you have to remove the pituitary tumor first."

Li Shiguang fondled his head, and the two of them were so tired that Professor Xu's teeth were sore.